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[DOI] [PubMed] [Google Scholar] 154.Mresse S., Delbart C., Fruchart J.-C., Cecchelli R

PHGDH is a critical rate-limiting enzyme in the serine biosynthesis pathway, and many tumor cells, particularly those in breast cancer, ovarian cancer, and others, exhibit overexpression of this enzyme

Hypoxia-inducible factors regulate osteoclasts in health and disease

its expression level has been retrospectively associated with poorer prognosis in pancreatic and lung cancer (349352)
