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37 Another meta-analysis, 38 including eight RCTs with a total of 526 patients with coronary artery disease (CAD), found that in this patient population, CoQ10 significantly lowered total cholesterol and increased HDL cholesterol but had no effect on triglycerides, whilst improvements in LDL cholesterol and lipoprotein(a) failed to reach statistical significance

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However, duplication events in the nematode lineage resulted in two genes encoding both AFMID and KMO (Fig