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Tissue gene expression data were normalized using the DESeq2 (ref
47 The most common AEs leading to discontinuation in the combined long-term studies were exacerbation/worsening of schizophrenia (14/368 [2.9%]), exacerbation of psychotic disorder (2/368 [0.4%]), and akathisia (2/368 [0.4%])
& Akiyama, H
Alternatively, combined delivery of gene editing tools and lipid metabolism inhibitors enables dual-level control over gene expression and lipid metabolic processes [20]
