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4 Resveratrol improves hyperandrogenemia HA, a hallmark of PCOS, manifests clinically as hirsutism, acne, alopecia, and ovulatory dysfunction ( Accumulating clinical research confirmed resveratrols therapeutic potential in PCOS through coordinated endocrine modulation, notably reducing FINS and androgen levels ( Concurrently, resveratrol enhances APN secretion, which orchestrates dual metabolic-androgenic regulation: Potentiation of IRS-dependent PI3K/Akt signaling restores hepatic insulin sensitivity, attenuating compensatory hyperinsulinemia-driven theca cell hyperactivity ( Overall, resveratrols anti-androgen synthesis effect may be attributed to its direct interference with the expression of enzymatic sabotage of cholesterol-to-androgen conversion machinery (HMGCR, CYP17A1)

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