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A double-blind, placebo-controlled trial could be helpful in exploring these questions (of note, the authors of this paper are currently conducting a clinical trial with secondary and exploratory outcomes aimed to explore symptomatic benefits, NCT04584346)
10.1136/bmjdrc-2019-001081 187 ZhangP.DongG.SunB.ZhangL.ChenX.MaN.et al (2011)
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