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Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

While these effects are generally manageable, they represent more pronounced GI side effects than observed with AOD-9604

The Quinlan 2022 study at 0.2mm with twice-weekly cadence is the closest signal we have, and it is a small (n=11) open-label study