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Hyperpigmentation is exclusively found in the papillae and usually has onset in childhood and is not progressive.2 The differential diagnosis includes Addison disease, Peutz-Jeghers syndrome, black hairy tongue, melanotic macule and melanocytic naevus.1 Paediatricians and paediatric dermatologists must be aware of this condition, as it can be diagnosed based on the clinical picture, avoiding the use of invasive tests.

With respect to LPC and LPS, although their total levels were not significantly modulated, we observed that overexpression of CRP was associated with an increase in 18:0 LPC, a decrease in 20:5 LPC and 22:6 LPC, and increases in 18:0 LPS, 20:5 LPS, and 22:6 LPS

[DOI] [PubMed] [Google Scholar] 14.Firth AN, Reade CP