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Indeed some practices achieve dramatic change: One practice reduced the number of patients on B12 injections from 53 to just two

doi: 10.1038/nprot.2018.020 84 NiaHTMunnLLJainRK

Large molecules with large molecular sizes cannot get into the pores of gel beads or easily pass through the column
10.1016/j.lungcan.2013.07.024 60 LehmannA
