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The NDA holder can use these exclusivities to migrate the patient population to the newer formulation before generic entry on the original product
Nat Rev Neurosci 2:727733 Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG (2000) ?-opioid receptor desensitization by -arrestin-2 determines morphine tolerance but not dependence
Table D2: Suitability for Recreation Grade Matrix Notes: * Indicates unexpected results requiring investigation (reassess SIC and MAC)
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