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Cerebral small vessel disease, the most prevalent cerebrovascular pathology, disrupts the myelin integrity of white matter through white matter hyperintensities (WMH), lacunar infarcts, and microbleeds, interfering with information transmission along white matter tracts [35]

Recently, a study involving human subjects found that elevated serum ferritin levels in liver donors were associated with a significant higher risk of liver damage in transplantation recipients [76], and blocking ferroptosis with compounds such as Fer-1, -tocopherol, and DFO prevented hepatic IRI [76]

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