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10.1016/S0166-6851(99)00185-1

Acta Sci Pol Technol Aliment 14(3):269276 Perriotte-Olson C, Adi N, Manickam DS, Westwood RA, Desouza CV, Natarajan G, Saraswathi V (2014) Nanoformulated copper/zinc superoxide dismutase reduces adipose inflammation in obesity

As a triple agonist , it simultaneously activates three distinct receptor systems [5]: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors enhance insulin secretion and may have direct effects on adipose tissue GLP-1 (Glucagon-like Peptide-1) receptors promote satiety, slow gastric emptying, and improve glucose regulation Glucagon receptors increase energy expenditure and may enhance fat oxidation This multi-receptor targeting strategy distinguishes retatrutide from single-pathway peptides and creates a complex metabolic profile that researchers are still working to fully characterize