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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

Cre Recombinase, a topoisomerase from bacteriophage P1, specifically recognizes and recombines the 2 loxP sites, excising the gene sandwiched in between

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