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Clinical trial data shows that exacerbation rates begin dropping by week 8, with maximal benefit achieved by weeks 16-24 of consistent mepolizumab severe asthma treatment . Timeline Expectations: Week 0-4: Blood eosinophils decrease (detectable in lab work) Week 4-8: Reduced rescue inhaler use, fewer nighttime symptoms Week 8-12: Noticeable improvement in asthma control, fewer exacerbations Week 12-24: Maximum benefit achieveddramatically fewer attacks, improved lung function Month 6+: Long-term stability with continued treatment Mepolizumab results vary based on baseline eosinophil count, severity of disease, and adherence to treatment