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In neuroblastoma, TRKB has the ability to up-regulate c-Met expression and augment the invasive potential of tumor cells [25]

Ozden and his colleagues reported that SIRT3 deacetylates the Pyruvate Dehydrogenase E1 Subunit Alpha 1 (PDHA1) subunit of pyruvate dehydrogenase complex (PDC) at the K321 position, thereby increasing its activity, which reverses the Warburg effect as glucose consumption and lactate production are reduced [83]

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ

Wan et al., 2019), subsequent studies have demonstrated heightened ORM2 levels in the hippocampal and frontal cortical regions of the brain during periods of heat stress, without concomitant elevations in ORM2 mRNA within the brain