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Gastroenterology 125 , 16701677 (2003)

B12 deficiency is more common with age, hypochlorhydria, small intestinal bacterial overgrowth, gastrointestinal bypass surgery, alcohol use, following a vegetarian or vegan diet, and use of medications such as proton-pump inhibitors, metformin, and hormonal contraceptives

Over the years, it has become increasingly evident that maintaining a stable intestinal barrier is crucial to prevent various potentially harmful substances and pathogens from entering the internal environment
