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M.HornigM.LettsR.SelvaggiC.AshktorabH.et al

Nat Rev Gastroenterol Hepatol (2017) 14:491502

[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

Inflammation & Immunological Research Investigated for its broad anti-inflammatory properties, including modulation of pro-inflammatory cytokines, reduction of C-reactive protein (CRP), and attenuation of systemic inflammatory markers in metabolic and non-metabolic disease models, suggesting potential research applications beyond classical endocrinological contexts