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reported on MSCs modified with Si NPs as a multifunctional platform for targeted delivery to the brain tumor (U87MG mice model) [359]
TABLE 3 Small molecules undergoing clinical trials and their safety outcomes
Wannamethee, S
Notably, while a 90% decline in on-treatment 2-HG levels by cycle 1 day 15 indicates successful on-target inhibitor activity, 2-HG suppression alone did not uniformly predict clinical response in enasidenib-treated patients
