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Interestingly, this enzyme enhances cysteine starvation-induced ferroptosis through activation of the GCN2-eIF2-ATF4 pathway in human triple negative breast cancer cells (60)
doi: 10.1016/s0165-6147(02)02072-2
In this review, we discuss the molecular functions of SLC7A11 in normal versus diseased tissues, with a special focus on how it regulates gastrointestinal cancers
Deshpande A, Bergami M, Ghanem A, Conzelmann KK, Lepier A, Gotz M, et al
