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Moreover, tBHP also promoted the release of high mobility group box 1 (HMGB1) into the culture supernatant, another marker of necrotic cell death 30 (Fig

Once formed, GSNO can release NO and cause intracellular death of the pathogen [70,71,72,73]

This breakthrough could dramatically improve patient outcomes, reduce long-term healthcare costs, and ultimately enhance life expectancy and quality for sufferers globally." This new research, part of Duke-NUS' efforts to develop biomedical solutions that improve the lives of patients, is supported by the National Research Foundation, Singapore under the National Medical Research Council (NMRC) Open Fund-Individual Research Grant (MOH-001625) and the Open Fund-Young Individual Research Grant (MOH-001130) and administered by the Singapore Ministry of Health through the NMRC Office, MOH Holdings Pte Ltd