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This limitation has driven the development of BDNF peptide mimetics , smaller synthetic molecules designed to activate the same TrkB pathways with greater stability and bioavailability
10.1016/j.semarthrit.2020.04.007 Pubmed Abstract CrossRef Google Scholar View reference in article 9
At the onset of RA, a large number of inflammatory factors such as TNF-, IL-6, IL-17, and IL-1 accumulate in the joints, causing inflammatory storms (121)
Using an ex vivo system of aged kidney slices FOXO4-DRI induced strong TUNEL positivity within 3 days (Fig
