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Furthermore, the uniform concentration profile across the bloodstream minimizes spatial variability, thereby avoiding the sampling-dependent gradients that frequently complicate ISF-based sensing modalities

Although this would diminish the ability to identify the direct antiviral properties of vitamin C in clinical studies it may have ancillary benefits of promoting general health, which may be particularly pertinent if administered in communities with greater deprivation or from less economically developed countries

However, the lack of reagents like antibodies, inhibitors, and cellspecific deletions for many SLE members remains a major hurdle [275]
Garrow TA, Brenner AA, Whitehead VM, Chen XN, Duncan RG, Korenberg JR, Shane B (1993) Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization
