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Additionally, cells generated by transplantation help reduce apoptosis, provide nutritional support through paracrine action, and enhance endogenous regeneration [104].The regeneration of endogenous neurons centres around GABAergic neurons, which serve as key inhibitory modulators of peri-infarct cortical plasticity [105] and are critical for post-stroke recovery [106]

Concurrently, insulin resistance, chronic inflammation, and obesity contribute to ROS overproduction, while the activity of antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) are significantly reduced ( In PCOS, excessive ROS inflict damage on oocytes and granulosa cells, disrupt the follicular microenvironment, and impair follicular development and ovulation ( e.g ., CYP17) in ovarian theca cells, exacerbating hyperandrogenemia ( e.g ., vitamin C, vitamin E, N-acetylcysteine) may mitigate oxidative damage, improve insulin sensitivity, and restore ovarian function by neutralizing ROS ( 3.2 Autophagy Autophagy is a fundamental cellular process responsible for degrading and recycling damaged organelles and proteins, playing a critical role in maintaining cellular homeostasis

Discussion KSs are a common urological disorder characterized by chronic inflammation and tissue injury, which significantly increases the risk of recurrence and perpetuates a vicious cycle [5]
