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It is essential to achieve a satisfactory combination of high levels of sustained -globin expression and the stable propagation of complex sequences

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

Additionally, the issue is exacerbated by traditional laboratories setting the 'normal' range too low, which may result in undiagnosed B12 deficiencies

Take care when opening your container, as mica easily becomes airborne