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Description
Given the preferences for glycolytic energy production in many tumor cell types, these findings suggest disruption of Fe-S cluster assembly and perturbation of IRP function could be used to further augment ferroptosis sensitivity cancer
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Shen, F.H., Samaetzis, D., Fessler, R.G
Meanwhile, the ferroptosis-mediated DAMP release may promote tumor progression by driving the polarization of macrophages in TME
