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These processes have been described in the healing of tendons, muscles, and skin wounds, suggesting that the mechanism of action is not limited to a specific tissue type but rather involves general cellular regulatory pathways

[38,39] Geroprotective effect of Metformin has been reported in multiple animal models including lifespan extension in Caenorhabditis elegans , Drosophila melanogaster and mice, and deceleration of aging clocks in male nonhuman primates

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This physiological effect contributes to increased satiety, reduced appetite, and improved postprandial glucose excursion