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While DHAR function in the ascorbate-glutathione pathway remains an outstanding candidate as a GSSG-generating enzyme, data from biochemical, transcriptomic and reverse genetics studies all suggest that other enzymes may contribute

As this phenomenon of synchronized RN is predominantly mediated by ferroptosis, IRI may critically involve the spreading of necrotic lesions within functional units such as a tubule or maybe between cardiomyocytes [91]

doi: 10.1016/j.plefa.2007.10.021
Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography