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neuronal glutathione synthesis in vivo Production of (GSH) astrocytes and neurons Reduced glutathione biosynthesis in Drosophila
Description
In NSCLC and other solid tumors, MARCO identifies a distinct subpopulation of tumor-associated macrophages that is often associated with T-lymphocyte exclusion and PD-L1 coexpression (220, 221)

PLoS ONE 5(4):e10206

This effect was not observed when either drug was administered alone, suggesting a synergistic mechanism

Future research should focus on optimizing combination therapies, refining tumor-specific delivery, and identifying predictive biomarkers to enhance therapeutic precision
