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This local iron overload in DSCs triggers ferroptosis through reduced GSH and glutathione peroxidase four levels with the concomitant increase in lipid and cellular ROS

5.2 Shortcomings of TCM in clinical studies Although TCM is currently receiving increasing attention worldwide as an alternative and complementary therapy for cancer treatment, there are some limitations in the published studies, such as the lack of scientific validity of the studies with large samples, multi-centre participation, randomised control and efficacy comparisons

10.1155/2022/5734549 45 WangW.WangC.XuH.GaoY

doi: 10.1371/journal.pone.0104986
