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Duration considerations All published FTPP studies used 28-day treatment cycles
10.1073/pnas.0610790104 274 WhiteF
KPV studies report effective anti-inflammatory concentrations in cell culture models at nanomolar to low micromolar ranges [7]
When blocking glucose metabolism, tumor cells rapidly adapt to metabolic inhibition by switching energy pathways (e.g., glutaminolysis or fatty acid oxidation), limiting the efficacy of glycolysis inhibitors like 2-DG or HK2-targeting agents [129]
