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In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression

At this point, it is unclear what the consequences of this local ROS accumulation at the ER-mitochondria MCS are, but ryanodine receptors 119 , IP 3 Rs and SERCA Ca 2+ pumps are known targets of ROS, which alter their activity 120

In germ free mice, Klebsiella pneumoniae lung infection leads to a limited neutrophil mobilization favoring the pathogen growth (76)
