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Further investigations were, however, performed on the most active series using a genetic approach based on RNA interference and highlighted a potential multi-target mechanism of action through topoisomerase II, mitotic spindle, HDAC and DNMT inhibition
Additionally, CytC plays a crucial role in apoptosis induction (139)
It was shown that when plants are under stress, amino acids build up in their tissues
These findings have motivated therapeutic strategies aimed at depleting GSH to promote tumor cell death
