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This is first clinical study demonstrating that a TfR antibody can deliver the enzyme IDS across the BBB into the brain for treatment of Hunter syndrome (mucopolysaccharidosis type II)

10.1038/ng.325 [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Baez-Duarte BG, Zamora-Ginez I, Mendoza-Carrera F, Ruiz-Vivanco G, Torres-Rasgado E, Gonzalez-Mejia ME, et al

However, thiol peroxidases contain Cys residues (Cys p

Elsevier, pp 2344 van Zandwijk N (1995) N-Acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with special reference to lung cancer
