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Recently IPH has been linked to plaque progression and vulnerability and nowadays is considered as a critical event in triggering atherosclerosis-associated acute clinical symptoms (Michel et al., 2011)
produced a NRPS/PKS hybrid, somocystinamide A ( 289 )
Of these, 6 (38%) experienced an irAE, with only 1 (6%) having a flare of the underlying rheumatologic disease 81
The clinical relevance of PDE5i has been proven in ischemia-reperfusion injury, pressure overload-induced hypertrophy, heart failure, myocardial ischemia (47, 48)
