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3.7.2 Other Amino Acids The regulatory role and metabolic fate of citrulline remain unclear, although citrulline can be metabolized into argininosuccinate (an inflammatory mediator) by the citrullineNO cycle

After a stable infection was established (68 weeks), mice were treated with different antibiotic triple therapies by oral gavage twice a day for 7 days: metronidazole or Metro-P3 (14.2 mg kg 1 day 1 ) or Metro-P3 (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) or MF-01 (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) or metronidazole (0.02 14.2 mg kg 1 day 1 = 0.30 mg kg 1 day 1 ) with clarithromycin (7.15 mg kg 1 day 1 ) or clarithromycin only (control group, 7.15 mg kg 1 day 1 )

Together, these results indicate that thecontrol compound8 does not release RSSH via intermolecular reactions in the presence of amines or thiols

(2007) 57:S335