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GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses

Only after establishing safety and pharmacokinetics can phase 2 efficacy trials in GERD patients proceed
6.2 Frequency of mutation In any population, one seed in one billion weed seeds is expected to express resistance through mutation
