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However sometimes you have the luxury of measured pH dependent solubilities and these can differ from the PK-sim calculated

[DOI] [PubMed] [Google Scholar] Chen L.S., Ma Y., Maubois J.L., Chen L.J., Liu Q.H., Guo J.P
Assessment of erectile function At 45th day after the first immunisation, the max intracavernous pressure (ICP) and the ratio of max ICP/mean systemic arterial pressure (MAP) were used to assess erectile function, which have been described previously [12]
10.1007/s00125-021-05380-z 13 ChatterjeeR.ChatterjeeJ