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Author contributions MY contributed to the collection, analysis, and interpretation of data as well as manuscript preparation

(B) The flavin-containing monooxygenase (FMO) enzyme, which is expressed by the FMO gene in the liver, kidney, and other tissues, converts the microbiome-derived TMA molecule into TMAO once it enters the host's circulation and reaches hepatocytes (43, 47, 48)

C.RomanoK

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