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It is noteworthy that novel pharmacological interventions may be more effective in light of the compromised BBB in SE (171)
In section 2.9 of the ICH S7A, conditions under which studies may not be necessary (e.g., locally applied products) and considerations for biologics are described
On the other hand, excessive VitE toxicity has been linked to headaches, weariness, dizziness, intestinal irritation, prolonged prothrombin time, and difficulty with the absorption of vitamins A and K
11 Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review
