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Concurrently, DAT enhances IRP binding to IRE-containing mRNAs, further modulating IRP/IRE-mediated iron homeostasis and promoting free iron accumulationoffering a novel transcriptional-level approach for single-agent ferroptosis induction (181)
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Intriguingly, in addition to GGT1, HLF also induces interleukin 6 (IL6) transcription, activating the JAK2/STAT3 axis to augment TGF1 secretion by TAMs, ultimately constituting a feedforward circuit to promote TNBC tumor growth
