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Since 90% of the SSc patients have Raynaud's syndrome preceding their onset of skin hardening by several years, and vasculopathy is often viewed that may be a key disease-driving cause of SSc, it is somewhat surprising that no vasculature-related genes have been described from the SSc GWAS studies so far

Research scope includes HPA axis stress modulation (approximately 30% cortisol reduction in human studies), neuroendocrine regulation, and pain modulation

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