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Gut flora-dependent metabolite trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

Decreased activity of complexes I and II is closely associated with reduced ATP production in cardiomyocytes of male obese rats with IR (117), and the inhibition of cytochrome c oxidase and complex IV deteriorates dysfunctional mitochondria and decreases ATP levels (118)

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References Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, Bellastella A, Carella C, Izzo A (2003) Serum and follicular fluid cytokines in PCOS during stimulated cycles