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The glutathione acts as a competitive inhibitor as the Km increases while the maximum velocity (Vmax) remains consistent with the increasing concentration of competitive inhibitor

A., Nadler, T

Mitochondrial dysfunction: NRF2 also orchestrates mitochondrial proteins such as superoxide mutase 1 (SOD1), which scavenges mitochondrial ROS and RNS to protect the mitochondrial respiratory chain from oxidative insults (Gumeni et al., 2021) and protein deglycase DJ-1 (PARK7), which maintains mitochondrial complex I activity and the mitochondrial membrane potential, two critical indicators for mitochondrial health (Hayashi et al., 2009

While GSH may be degraded, transported as amino acids, and resynthesized in the cell, there may also be circumstances where GSH is transported into cells without degradation