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This suggested that the CD36/MAPK/JNK pathway may play a key role in TMAO-induced foam cell formation ( in vitro study found that different concentrations of TMAO have no effect on the formation of foam cells in mouse macrophages ( The NLRP3 inflammasome is a polyprotein complex formed by the activation of PRRs that was recently reported to be crucial for the development of AS (Martinon et al., 2002