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M., Zhang H., Pahl E., Purves R
5.1 Pharmacological approaches Pharmacological interventions in macrophage polarization employ diverse targeting strategies to remodel the immune microenvironment by modulating key signaling pathways and metabolic reprogramming ( Figure 5 )

fumigatus triggers proangiogenic effects, including the production of proinflammatory factors such as tumor necrosis factor alpha (TNF), hypoxia-inducible factor 1-alpha (HIF1), and interleukin (IL-8), thus recruiting the polymorphonuclear leucocytes (PMNLs) and leading to the burst of ROS, including H 2 O 2

Under the optimal cut-off value, the models sensitivity was 92.6% (50/54) and the specificity was 93.7% (44/47), and the average accuracy based on 100 cross validations was 88.9% ( Figure 4 )
