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Statistical significance was calculated by two-way ANOVA followed by Dunnetts multiple comparisons test with Bmal1 -KO set as the reference group in a (right panel), and a and d , and ANCOVA in b , and one-way ANOVA followed by multiple comparisons in e-g

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The supernatant was used for the analysis of LPO (Reference Ledwozyw, Michalak and Stepie25) , nitric oxide (NO) (Reference Miranda, Espey and Wink26) , GSH (Reference Beutler27) , glutathione-S-transferase (GST) (Reference Habig and Jakoby28) , SOD (Reference Mylroie, Collins and Umbles29) and tissue factor (TF) (Reference Ingram30) activities