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Lipid Profile Improvements Treatment with retatrutide resulted in favorable changes to lipid profiles: Reduced triglycerides, with bias toward reduction in short-chain and saturated species Decreased LDL and VLDL cholesterol Improved markers associated with enhanced insulin sensitivity and reduced systemic inflammation[3] These changes in lipid metabolism may contribute to retatrutide's cardiometabolic benefits and warrant further investigation for potential cardiovascular outcome benefits

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Ex vivo incubation of the venous samples with 1,25(OH)2D3 resulted in: (i) significant reduction in ROS level, (ii) upregulation of eNOS and nNOS expression, and (iii) downregulation of iNOS expression in both groups of patients