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The benefits of cladribine for the treatment of progressive MS remains to be explored in further clinical trials (ClinicalTrials.gov NCT04695080, NCT04550455)

The CaMV 35S minimal promoter (-46 to +7) fused to the GUS gene from pBT-GUS [45] was cloned as a BamHI and XmaI fragment into pPAM (GenBank AY027531)

These last steps were not simulated as this would require more complex systems, as well as longer timescales, both beyond the limitations of the used computational method (DFTB)

Due to the pathologic implication of oxidative stress in FRDA, attempts have been and are being made to develop drugs which can counteract the impact of oxidative stress in FRDA