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Glucocorticoid treatment of cultured rat cardiomyocytes protects the cells against ischemia-induced apoptosis by inducing the expression of lipocalin-type prostaglandin D synthase (L-PGDS), which induces prostaglandin biosynthesis, limiting the inflammatory response and tissue damage [84]

Renal blood perfusion decreased significantly by 6 h and reached its lowest point at 24 h, with glycocalyx thinning becoming evident [21]

The study found the peptide well-tolerated with minimal toxicity risk, though adverse events were described as mild to moderate

Patients should aim to drink water regularly rather than waiting until they feel thirsty, as thirst is often a late indicator of dehydration