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[DOI] [PubMed] [Google Scholar] 49.Beutler E
High stress increases cortisol, which damages pigment cells and speeds up greying
For example, when investigating the hypothesis that gap junctions transport toxic metabolites to neighboring cells and support their killing during APAP and thioacetamide hepatotoxicity, the fact that the new gap junction inhibitor 2-aminoethoxydipenyl-borate (2APB) protected against the injury appeared to support the hypothesis [154]
It typically points to one of two underlying mechanisms: infiltrating neoplasia or edema (often driven by an inflammatory response)
