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Aamodt SM, Shi J, Colonnese MT, Veras W, Constantine-Paton M

The ZIP family facilitates the influx of zinc into the cytosol from either the extracellular space or intracellular organelles, whereas the ZnT family exports zinc from the cytosol to organelles or out of the cell 15,30

The relative gene expression in relation to the -actin was calculated using the 2 Ct technique (Pfaffl 2001

It was suggested that PX-478 lowers HIF-1 levels by affecting multiple levels in the HIF-1 pathway: (1) inhibition of HIF-1 deubiquitination via p53 and pVHL independent mechanism, resulting in increased levels of polyubiquitinated HIF-1